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Details on Person CTBP1,CTBP2 binds ZEB1

Class:IdReaction:9765973
_displayNameCTBP1,CTBP2 binds ZEB1
_doReleaseTRUE
_timestamp2025-05-23 13:33:33
authored[InstanceEdit:9765972] Orlic-Milacic, Marija, 2022-02-17
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9765972] Orlic-Milacic, Marija, 2022-02-17
edited[InstanceEdit:9930966] Orlic-Milacic, Marija, 2024-12-07
input[EntityWithAccessionedSequence:6789836] ZEB1 [nucleoplasm] [Homo sapiens]
[DefinedSet:9931725] CTBP1,CTBP2 dimers [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9765962] MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP
[LiteratureReference:9931724] ZEB represses transcription through interaction with the corepressor CtBP
[LiteratureReference:9931732] BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial-mesenchymal transition process
modified[InstanceEdit:9815985] Orlic-Milacic, Marija, 2022-08-31
[InstanceEdit:9930958] Orlic-Milacic, Marija, 2024-12-07
[InstanceEdit:9930967] Orlic-Milacic, Marija, 2024-12-07
[InstanceEdit:9931729] Orlic-Milacic, Marija, 2024-12-12
[InstanceEdit:9931734] Orlic-Milacic, Marija, 2024-12-12
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
nameCTBP1,CTBP2 binds ZEB1
output[Complex:9765959] CTBP1,CTBP2:ZEB1 [nucleoplasm] [Homo sapiens]
regulatedBy[NegativeRegulation:9765963] Negative regulation by 'MCRIP1:CTBP1 [nucleoplasm]'
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9765978] R-HSA-9765973.1
structureModified[InstanceEdit:9930958] Orlic-Milacic, Marija, 2024-12-07
[InstanceEdit:9931729] Orlic-Milacic, Marija, 2024-12-12
summation[Summation:9815984] ZEB1 forms a complex with CTBP1 (CtBP) (Postigo and Dean 199...
(hasEvent)[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)[Reaction:9764741] ZEB1 binds CDH1 gene promoter [Homo sapiens]
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