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Details on Person TCF3 represses CDH1 gene transcription

Class:Id	BlackBoxEvent:9765756
_displayName	TCF3 represses CDH1 gene transcription
_doRelease	TRUE
_timestamp	2025-05-23 13:36:52
authored	[InstanceEdit:9765752] Orlic-Milacic, Marija, 2022-02-16
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9765752] Orlic-Milacic, Marija, 2022-02-16
edited	[InstanceEdit:9931380] Orlic-Milacic, Marija, 2024-12-11
input	[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9765763] PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer [LiteratureReference:9931369] Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition
modified	[InstanceEdit:9931380] Orlic-Milacic, Marija, 2024-12-11 [InstanceEdit:9931759] Orlic-Milacic, Marija, 2024-12-12 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	TCF3 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9765742] TCF3 binds CDH1 gene promoter [Homo sapiens] [BlackBoxEvent:9765765] TCF3 (E47) translocates to the nucleus [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9931377] Negative gene expression regulation by 'TCF3:CDH1 gene [nucleoplasm]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9765769] R-HSA-9765756.1
structureModified	[InstanceEdit:9931380] Orlic-Milacic, Marija, 2024-12-11
summation	[Summation:9931376] TCF3 (also known as E47) directly represses CDH1 gene transc...
(hasEvent)	[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9954073] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954085] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954095] Negative relationship: TCF3 represses CDH1 gene transcription [NegativePrecedingEvent:9954103] Negative relationship: TCF3 represses CDH1 gene transcription
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No pathways have been reviewed or authored by TCF3 represses CDH1 gene transcription (9765756)