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Details on Person ZEB2 binds CDH1 gene promoter

Class:IdReaction:9765313
_displayNameZEB2 binds CDH1 gene promoter
_doReleaseTRUE
_timestamp2025-05-23 13:38:00
authored[InstanceEdit:9765220] Orlic-Milacic, Marija, 2022-02-15
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9765316] Orlic-Milacic, Marija, 2022-02-15
edited[InstanceEdit:9930669] Orlic-Milacic, Marija, 2024-12-05
input[EntityWithAccessionedSequence:3108222] ZEB2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9765331] Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression
[LiteratureReference:9765311] Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression
[LiteratureReference:9765342] ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat-Wilson syndrome
modified[InstanceEdit:9765334] Orlic-Milacic, Marija, 2022-02-15
[InstanceEdit:9765351] Orlic-Milacic, Marija, 2022-02-15
[InstanceEdit:9765478] Orlic-Milacic, Marija, 2022-02-15
[InstanceEdit:9768591] Orlic-Milacic, Marija, 2022-03-11
[InstanceEdit:9768691] Orlic-Milacic, Marija, 2022-03-14
[InstanceEdit:9793559] Orlic-Milacic, Marija, 2022-06-20
[InstanceEdit:9815541] Orlic-Milacic, Marija, 2022-08-18
[InstanceEdit:9815542] Orlic-Milacic, Marija, 2022-08-18
[InstanceEdit:9815546] Orlic-Milacic, Marija, 2022-08-18
[InstanceEdit:9815547] Orlic-Milacic, Marija, 2022-08-18
[InstanceEdit:9815694] Orlic-Milacic, Marija, 2022-08-25
[InstanceEdit:9930724] Orlic-Milacic, Marija, 2024-12-05
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
nameZEB2 binds CDH1 gene promoter
output[Complex:9793552] ZEB2:CDH1 gene [nucleoplasm] [Homo sapiens]
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9765323] R-HSA-9765313.1
summation[Summation:9793557]

Direct binding of ZEB2 (Zinc finger E-box-binding homeobo...

(hasEvent)[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(normalReaction)[FailedReaction:9815642] Defective ZEB2 does not bind CDH1 gene promoter [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9765293] ZEB2 represses CDH1 gene transcription [Homo sapiens]
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No pathways have been reviewed or authored by ZEB2 binds CDH1 gene promoter (9765313)
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