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Details on Person TWIST2 binds CDH1 gene promoter

Class:IdReaction:9765169
_displayNameTWIST2 binds CDH1 gene promoter
_doReleaseTRUE
_timestamp2025-05-23 13:37:07
authored[InstanceEdit:9765166] Orlic-Milacic, Marija, 2022-02-14
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9765166] Orlic-Milacic, Marija, 2022-02-14
edited[InstanceEdit:9931115] Orlic-Milacic, Marija, 2024-12-10
input[EntityWithAccessionedSequence:445444] TWIST2 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9765162] HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer
[LiteratureReference:9764915] Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer
modified[InstanceEdit:9931095] Orlic-Milacic, Marija, 2024-12-10
[InstanceEdit:9931103] Orlic-Milacic, Marija, 2024-12-10
[InstanceEdit:9931107] Orlic-Milacic, Marija, 2024-12-10
[InstanceEdit:9931759] Orlic-Milacic, Marija, 2024-12-12
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
nameTWIST2 binds CDH1 gene promoter
output[Complex:9931099] TWIST2:CDH1 gene [nucleoplasm] [Homo sapiens]
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9765178] R-HSA-9765169.1
structureModified[InstanceEdit:9931103] Orlic-Milacic, Marija, 2024-12-10
summation[Summation:9931106] Binding of TWIST2 to the CDH1 gene promoter was demonstrated...
(hasEvent)[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9765175] TWIST2 represses CDH1 gene transcription [Homo sapiens]
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No pathways have been reviewed or authored by TWIST2 binds CDH1 gene promoter (9765169)