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Details on Person TWIST1 binds CDH1 gene promoter

Class:IdReaction:9765015
_displayNameTWIST1 binds CDH1 gene promoter
_doReleaseTRUE
_timestamp2025-05-23 13:36:57
authored[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9765059] Orlic-Milacic, Marija, 2022-02-14
edited[InstanceEdit:9930669] Orlic-Milacic, Marija, 2024-12-05
input[EntityWithAccessionedSequence:445442] TWIST1 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9765058] Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
[LiteratureReference:9765014] The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
[LiteratureReference:9765107] SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
modified[InstanceEdit:9765116] Orlic-Milacic, Marija, 2022-02-14
[InstanceEdit:9765133] Orlic-Milacic, Marija, 2022-02-14
[InstanceEdit:9765180] Orlic-Milacic, Marija, 2022-02-14
[InstanceEdit:9815694] Orlic-Milacic, Marija, 2022-08-25
[InstanceEdit:9815754] Orlic-Milacic, Marija, 2022-08-26
[InstanceEdit:9815857] Orlic-Milacic, Marija, 2022-08-29
[InstanceEdit:9930728] Orlic-Milacic, Marija, 2024-12-05
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
nameTWIST1 binds CDH1 gene promoter
output[Complex:9815640] TWIST1:CDH1 gene [nucleoplasm] [Homo sapiens]
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9765063] R-HSA-9765015.1
summation[Summation:9815752] Binding of transcription factor TWIST1 to CDH1 (E-cadherin) ...
(hasEvent)[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9765049] TWIST1 represses CDH1 gene transcription [Homo sapiens]
[Reaction:9765788] TWIST1 recruits SETD8 to CDH1 gene promoter [Homo sapiens]
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