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Details on Person PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter

Class:IdReaction:9764932
_displayNamePRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter
_doReleaseTRUE
_timestamp2025-06-05 18:26:45
authored[InstanceEdit:9764823] Orlic-Milacic, Marija, 2022-02-14
catalystActivity[CatalystActivity:9815908] histone H3K27 methyltransferase activity of PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9764937] Orlic-Milacic, Marija, 2022-02-14
edited[InstanceEdit:9930831] Orlic-Milacic, Marija, 2024-12-06
input[Complex:9815907] PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9764966] Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells
[LiteratureReference:9764954] EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β
modified[InstanceEdit:9764996] Orlic-Milacic, Marija, 2022-02-14
[InstanceEdit:9815882] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9815886] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9815901] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9815904] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9815912] Orlic-Milacic, Marija, 2022-08-30
[InstanceEdit:9930831] Orlic-Milacic, Marija, 2024-12-06
[InstanceEdit:9930832] Orlic-Milacic, Marija, 2024-12-06
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
[InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
namePRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter
output[Complex:9815909] PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent
releaseDate2025-06-18
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9764938] R-HSA-9764932.2
summation[Summation:9815881] In human lung and colon cancer cell lines, increased occupan...
(hasEvent)[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9764934] PRC2 (EZH2) mediates repression of CDH1 gene transcription [Homo sapiens]
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No pathways have been reviewed or authored by PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (9764932)