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Details on Person MIER3 mediates repression of CDH1 gene transcription

Class:Id	BlackBoxEvent:9764842
_displayName	MIER3 mediates repression of CDH1 gene transcription
_doRelease	FALSE
_timestamp	2025-01-17 17:43:10
authored	[InstanceEdit:9765150] Orlic-Milacic, Marija, 2022-02-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9764836] Orlic-Milacic, Marija, 2022-02-14
edited	[InstanceEdit:9930698] Orlic-Milacic, Marija, 2024-12-05
input	[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9764838] MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail [LiteratureReference:9765256] SNAI1 interacts with HDAC1 to control TGF‑β2‑induced epithelial‑mesenchymal transition in human lens epithelial cells
modified	[InstanceEdit:9765257] Orlic-Milacic, Marija, 2022-02-15 [InstanceEdit:9796430] Orlic-Milacic, Marija, 2022-08-09 [InstanceEdit:9796443] Orlic-Milacic, Marija, 2022-08-09 [InstanceEdit:9930699] Orlic-Milacic, Marija, 2024-12-05 [InstanceEdit:9935648] Orlic-Milacic, Marija, 2025-01-17
name	MIER3 mediates repression of CDH1 gene transcription
output	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9764835] MIER3 forms a repressive complex with HDAC1, HDAC2 and SNAI1 at the CDH1 gene promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9796428] Negative gene expression regulation by 'MIER3:HDAC1,HDAC2:SNAI1:CDH1 gene [nucleoplasm]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9764847] R-HSA-9764842.1
summation	[Summation:9796441] The complex of SNAI1 and HDAC1 was reported to repress CDH1 ...
(hasEvent)	[Pathway:9815367] (InsufficientEvidenceEvents)NegativeRegulationOfCDH1GeneTranscription [Homo sapiens]
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No pathways have been reviewed or authored by MIER3 mediates repression of CDH1 gene transcription (9764842)