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Details on Person DNTTIP1 and KDM1A repress CDH1 gene transcription

Class:Id	BlackBoxEvent:9764827
_displayName	DNTTIP1 and KDM1A repress CDH1 gene transcription
_doRelease	TRUE
_timestamp	2025-05-23 13:33:47
authored	[InstanceEdit:9764823] Orlic-Milacic, Marija, 2022-02-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9764823] Orlic-Milacic, Marija, 2022-02-14
edited	[InstanceEdit:9930829] Orlic-Milacic, Marija, 2024-12-06
input	[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9764816] TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer [LiteratureReference:9930826] High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
modified	[InstanceEdit:9815869] Orlic-Milacic, Marija, 2022-08-30 [InstanceEdit:9815877] Orlic-Milacic, Marija, 2022-08-30 [InstanceEdit:9930829] Orlic-Milacic, Marija, 2024-12-06 [InstanceEdit:9930830] Orlic-Milacic, Marija, 2024-12-06 [InstanceEdit:9935648] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	DNTTIP1 and KDM1A repress CDH1 gene transcription
output	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9764826] DNTTIP1 recruits KDM1A to CDH1 gene promoter [Homo sapiens] [Reaction:9764811] DNTTIP1 binds CDH1 gene promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9815873] Negative gene expression regulation by 'KDM1A:DNTTIP1:CDH1 gene [nucleoplasm]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9764830] R-HSA-9764827.1
summation	[Summation:9815863] DNTTIP1 (TdIF1) forms a complex with histone demethylase KDM...
(hasEvent)	[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9954074] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954079] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954086] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription [NegativePrecedingEvent:9954110] Negative relationship: DNTTIP1 and KDM1A repress CDH1 gene transcription
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No pathways have been reviewed or authored by DNTTIP1 and KDM1A repress CDH1 gene transcription (9764827)