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Details on Person SP1 stimulates CDH1 gene transcription

Class:Id	BlackBoxEvent:9764800
_displayName	SP1 stimulates CDH1 gene transcription
_doRelease	TRUE
_timestamp	2025-05-23 13:36:36
authored	[InstanceEdit:9764858] Orlic-Milacic, Marija, 2022-02-14
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
edited	[InstanceEdit:9930641] Orlic-Milacic, Marija, 2024-12-04
input	[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9764763] Transcriptional repression of E-cadherin in nickel-exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter [LiteratureReference:9764783] Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression [LiteratureReference:9766461] Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21(Cip1) by modulating the transcription factor Sp1
modified	[InstanceEdit:9793370] Orlic-Milacic, Marija, 2022-06-10 [InstanceEdit:9793509] Orlic-Milacic, Marija, 2022-06-16 [InstanceEdit:9793510] Orlic-Milacic, Marija, 2022-06-16 [InstanceEdit:9930643] Orlic-Milacic, Marija, 2024-12-04 [InstanceEdit:9935648] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	SP1 stimulates CDH1 gene transcription
output	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9764791] SP1 binds CDH1 gene promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9793368] Positive gene expression regulation by 'SP1:CDH1 gene [nucleoplasm]' [NegativeRegulation:9793504] Negative regulation by 'STRAP [cytosol]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9764808] R-HSA-9764800.1
summation	[Summation:9793364] CDH1 gene transcription is directly stimulated by the transc...
(hasEvent)	[Pathway:9764790] Positive Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9768614] miR-9 inhibits CDH1 mRNA translation [Homo sapiens] [Reaction:9768616] miR-9 binds CDH1 mRNA [Homo sapiens] [BlackBoxEvent:9768618] miR-10b inhibits CDH1 mRNA translation [Homo sapiens] [Reaction:9768643] miR-10b binds CDH1 mRNA [Homo sapiens]
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No pathways have been reviewed or authored by SP1 stimulates CDH1 gene transcription (9764800)