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Details on Person ZEB1 represses CDH1 gene transcription

Class:Id	BlackBoxEvent:9764778
_displayName	ZEB1 represses CDH1 gene transcription
_doRelease	TRUE
_timestamp	2025-05-23 13:37:57
authored	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9764775] Orlic-Milacic, Marija, 2022-02-14
edited	[InstanceEdit:9930669] Orlic-Milacic, Marija, 2024-12-05
input	[EntityWithAccessionedSequence:9756422] CDH1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9764759] ZEB1 recruit Brg1 to regulate airway remodeling epithelial-mesenchymal transition in asthma [LiteratureReference:9764753] Brg1 inhibits E-cadherin expression in lung epithelial cells and disrupts epithelial integrity [LiteratureReference:9764733] ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 [LiteratureReference:9768099] E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing [LiteratureReference:9764769] TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression [LiteratureReference:9815627] TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin [LiteratureReference:9930710] The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells [LiteratureReference:9765789] SET8 induces epithelial‑mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1 [LiteratureReference:9765848] MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition
modified	[InstanceEdit:9765497] Orlic-Milacic, Marija, 2022-02-15 [InstanceEdit:9815399] Orlic-Milacic, Marija, 2022-08-17 [InstanceEdit:9815548] Orlic-Milacic, Marija, 2022-08-18 [InstanceEdit:9815694] Orlic-Milacic, Marija, 2022-08-25 [InstanceEdit:9930717] Orlic-Milacic, Marija, 2024-12-05 [InstanceEdit:9930720] Orlic-Milacic, Marija, 2024-12-05 [InstanceEdit:9930724] Orlic-Milacic, Marija, 2024-12-05 [InstanceEdit:9931120] Orlic-Milacic, Marija, 2024-12-10 [InstanceEdit:9931125] Orlic-Milacic, Marija, 2024-12-10 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
name	ZEB1 represses CDH1 gene transcription
output	[EntityWithAccessionedSequence:9793365] CDH1 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9764786] ZEB1 recruits SMARCA4 to CDH1 gene promoter [Homo sapiens] [Reaction:9764741] ZEB1 binds CDH1 gene promoter [Homo sapiens] [Reaction:9930711] ZEB1 recruits TLE1 and HDAC1/2 to CDH1 gene promoter [Homo sapiens] [Reaction:9764741] ZEB1 binds CDH1 gene promoter [Homo sapiens] [Reaction:9765791] ZEB1 recruits SETD8 to CDH1 gene promoter [Homo sapiens] [Reaction:9764741] ZEB1 binds CDH1 gene promoter [Homo sapiens] [Reaction:9765850] ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter [Homo sapiens] [Reaction:9764741] ZEB1 binds CDH1 gene promoter [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9815610] Negative gene expression regulation by 'ZEB1:CDH1 gene, SMARCA4:ZEB1:CDH1 gene, HDAC1,(HDAC2):TLE1:ZEB1:CDH1 gene, (SETD8:ZEB1:CDH1 gene, SIRT1:MPHOSPH8:ZEB1:CDH1 gene) [nucleoplasm]'
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9764807] R-HSA-9764778.1
summation	[Summation:9815397] Direct repression of CDH1 gene transcription was first de...
(hasEvent)	[Pathway:9764725] Negative Regulation of CDH1 Gene Transcription [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9954071] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954075] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954087] Negative relationship: ZEB1 represses CDH1 gene transcription [NegativePrecedingEvent:9954111] Negative relationship: ZEB1 represses CDH1 gene transcription
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No pathways have been reviewed or authored by ZEB1 represses CDH1 gene transcription (9764778)