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Details on Person p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12

Class:Id	BlackBoxEvent:9763892
_displayName	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
_doRelease	TRUE
_timestamp	2022-10-09 06:48:15
authored	[InstanceEdit:9763895] May, Bruce, 2022-02-06
catalystActivity	[CatalystActivity:9763904] ubiquitin protein ligase activity of Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Cbl [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9763878] May, Bruce, 2022-02-07
edited	[InstanceEdit:9763895] May, Bruce, 2022-02-06
input	[CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [CandidateSet:517946] Ubiquitin [cytosol] [Mus musculus] [Complex:9763880] Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Cbl [plasma membrane] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9682750] A CSF-1 receptor phosphotyrosine 559 signaling pathway regulates receptor ubiquitination and tyrosine phosphorylation [LiteratureReference:9763905] The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation [LiteratureReference:9680735] CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins [LiteratureReference:9763951] c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages
modified	[InstanceEdit:9763956] May, Bruce, 2022-02-07 [InstanceEdit:9766337] May, Bruce, 2022-02-18 [InstanceEdit:9818020] May, Bruce, 2022-10-08 [InstanceEdit:9818021] May, Bruce, 2022-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12
output	[Complex:9763896] Csf1 dimer:PolyUb,p-Y559-Csf1r:Fyn,Hck,Src,Yes1:PolyUb,p-Y-Cbl [plasma membrane] [Mus musculus]
releaseDate	2022-12-07
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9763907] R-MMU-9763892.2
summation	[Summation:9766316] After Cbl is phosphorylated and binds Csf1r, Cbl autopolyubi...
(inferredFrom)	[BlackBoxEvent:9733316] p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL [Homo sapiens]
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