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Details on Person Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
| Class:Id | LiteratureReference:9763394 |
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| _displayName | Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations |
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| _timestamp | 2022-02-02 17:20:33 |
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| author | [Person:9763387] Pollard, P J
[Person:9763382] Brière, J J
[Person:9763389] Alam, N A
[Person:9763385] Barwell, J
[Person:9763386] Barclay, E
[Person:9023103] Wortham, N C
[Person:68997] Hunt, T
[Person:9763384] Mitchell, M
[Person:9763380] Olpin, S
[Person:9763392] Moat, S J
[Person:9763388] Hargreaves, I P
[Person:9763377] Heales, S J
[Person:9763381] Chung, Y L
[Person:9763393] Griffiths, J R
[Person:9763378] Dalgleish, A
[Person:9683697] McGrath, J A
[Person:9763383] Gleeson, M J
[Person:9763376] Hodgson, S V
[Person:9763379] Poulsom, R
[Person:198402] Rustin, P
[Person:9763390] Tomlinson, I P M |
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| created | [InstanceEdit:9763391] Rothfels, Karen, 2022-02-02 |
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| journal | Hum Mol Genet |
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| pages | 2231-9 |
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| pubMedIdentifier | 15987702 |
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| title | Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations |
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| volume | 14 |
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| year | 2005 |
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| (literatureReference) | [RegulationReference:9767140] Negative regulation by 'SUCCA: PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]' Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
[Reaction:70994] SDH complex dehydrogenates succinate [Homo sapiens]
[Pathway:71403] Citric acid cycle (TCA cycle) [Homo sapiens]
[Reaction:1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A [Homo sapiens]
[Reaction:9767129] SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [Homo sapiens] |
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