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Details on Person Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
| Class:Id | LiteratureReference:9763362 |
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| _displayName | Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF |
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| _timestamp | 2022-02-02 17:19:45 |
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| author | [Person:9763360] Koivunen, Peppi
[Person:9763363] Hirsilä, Maija
[Person:9763359] Remes, Anne M
[Person:9763361] Hassinen, Ilmo E
[Person:8862403] Kivirikko, Kari I
[Person:2566490] Myllyharju, Johanna |
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| created | [InstanceEdit:9763364] Rothfels, Karen, 2022-02-02 |
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| journal | J Biol Chem |
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| pages | 4524-4532 |
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| pubMedIdentifier | 17182618 |
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| title | Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF |
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| volume | 282 |
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| year | 2007 |
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| (literatureReference) | [RegulationReference:9767140] Negative regulation by 'SUCCA: PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]' Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
[Reaction:70994] SDH complex dehydrogenates succinate [Homo sapiens]
[Reaction:1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A [Homo sapiens]
[Reaction:9767129] SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [Homo sapiens] |
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