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Details on Person Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
| Class:Id | LiteratureReference:9763328 |
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| _displayName | Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase |
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| _timestamp | 2022-02-02 17:18:59 |
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| author | [Person:5628857] Selak, Mary A
[Person:9763326] Armour, Sean M
[Person:9763323] MacKenzie, Elaine D
[Person:6804249] Boulahbel, Houda
[Person:9763325] Watson, David G
[Person:9763324] Mansfield, Kyle D
[Person:3465470] Pan, Yi
[Person:8866339] Simon, M Celeste
[Person:140401] Thompson, CB
[Person:5628861] Gottlieb, Eyal |
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| created | [InstanceEdit:9763327] Rothfels, Karen, 2022-02-02 |
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| journal | Cancer Cell |
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| pages | 77-85 |
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| pubMedIdentifier | 15652751 |
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| title | Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase |
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| volume | 7 |
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| year | 2005 |
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| (literatureReference) | [Reaction:70994] SDH complex dehydrogenates succinate [Homo sapiens]
[Reaction:1234177] Cytosolic PHD2,3 hydroxylates proline residues on HIF1A [Homo sapiens]
[Reaction:9767129] SUCCA binds PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [Homo sapiens]
[RegulationReference:9767140] Negative regulation by 'SUCCA: PHD2,3:LIMD1, AJUBA, WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol]' Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase |
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