Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Binding of the C-terminal fragment of angiopoietin-like 4, c...
| Class:Id | Summation:9762289 |
|---|---|
| _displayName | Binding of the C-terminal fragment of angiopoietin-like 4, c... |
| _timestamp | 2022-06-09 20:31:58 |
| created | [InstanceEdit:9762288] Orlic-Milacic, Marija, 2022-01-19 |
| modified | [InstanceEdit:9762339] Orlic-Milacic, Marija, 2022-01-19 [InstanceEdit:9793106] Orlic-Milacic, Marija, 2022-06-02 [InstanceEdit:9793237] Orlic-Milacic, Marija, 2022-06-09 [InstanceEdit:9793238] Orlic-Milacic, Marija, 2022-06-09 |
| text | Binding of the C-terminal fragment of angiopoietin-like 4, commonly known as cANGPTL4 and in this diagram labeled as ANGPTL4(164-406), to the extracellular region of CDH11 leads to release of CDH11-bound CTNNB1 (beta-catenin) to the cytosol. This CTNNB1 release is independent of activation of WNT receptors. cANGPTL4 upregulates transcription of ID3 (Inhibitor of DNA-binding/differentiation protein 3) in a CDH11- and CTNBB1-dependent manner. ID3 forms a complex with a basic helix-loop-helix (bHLH) transcription factor scleraxis (SCX), and this complex inhibits scar-associated production of collagens COL1A2 and COL3A1 by fibroblasts (Teo et al. 2017). The variant isoform of CDH11 (CDH11v), which does not possess the cytoplasmic domain and does not bind CTNNB1, can compete with the canonical CDH11 for cANGPTL4 binding, leading to diminished CTNNB1 release (Teo et al. 2017). |
| (summation) | [Reaction:9762282] CTNNB1 dissociates from CDH11 upon ANGPTL4 binding [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Binding of the C-terminal fragment of angiopoietin-like 4, c... (9762289)
