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Details on Person Ub,pS335,S338,T NFE2L2 is degraded

Class:Id	BlackBoxEvent:9762096
_displayName	Ub,pS335,S338,T NFE2L2 is degraded
_doRelease	TRUE
_timestamp	2022-02-28 16:33:55
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9762099] Rothfels, Karen, 2022-01-17
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[Complex:9762077] BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761995] SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner [LiteratureReference:9762014] Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9762027] The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
modified	[InstanceEdit:9762212] Rothfels, Karen, 2022-01-18 [InstanceEdit:9767058] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ub,pS335,S338,T NFE2L2 is degraded
output	[Complex:9762080] BTRC:SKP1:RBX1:CUL1 [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 [Homo sapiens] [Reaction:9762093] BTRC binds p-S344, 347 NFE2L2 [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9762105] R-HSA-9762096.2
summation	[Summation:9762068] After BTRC:CUL1-mediated ubiquitination, NFE2L2 is degraded ...
(hasEvent)	[Pathway:9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9767157] Futile Cycle: Ub,pS335,S338,T NFE2L2 is degraded
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No pathways have been reviewed or authored by Ub,pS335,S338,T NFE2L2 is degraded (9762096)