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Details on Person BTRC binds p-S344, 347 NFE2L2

Class:IdReaction:9762093
_displayNameBTRC binds p-S344, 347 NFE2L2
_doReleaseTRUE
_timestamp2022-12-29 21:57:41
authored[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9762099] Rothfels, Karen, 2022-01-17
edited[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input[CandidateSet:9762061] p-S344, 347 NFE2L2 [nucleoplasm] [Homo sapiens]
[Complex:9762080] BTRC:SKP1:RBX1:CUL1 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9761948] Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
[LiteratureReference:9761995] SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
[LiteratureReference:9762014] Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis
[LiteratureReference:9762004] Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
[LiteratureReference:9762027] The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
modified[InstanceEdit:9767009] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767159] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
[InstanceEdit:9822894] D'Eustachio, Peter, 2022-12-29
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameBTRC binds p-S344, 347 NFE2L2
negativePrecedingEvent[NegativePrecedingEvent:9767157] Futile Cycle: Ub,pS335,S338,T NFE2L2 is degraded
output[Complex:9762081] BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2022-03-23
reviewed[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9762109] R-HSA-9762093.3
summation[Summation:9762072] In response to GSK3B-dependent phosphorylation at, minimally...
(hasEvent)[Pathway:9762114] GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 [Homo sapiens]
(precedingEvent)[Reaction:9762091] NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9846712] Update Tracker - [Reaction:9762093] BTRC binds p-S344, 347 NFE2L2 - v84:[modifyText]
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