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Details on Person Chronic hepatitis B virus (HBV) infection stimulates express...
| Class:Id | Summation:9761878 |
|---|---|
| _displayName | Chronic hepatitis B virus (HBV) infection stimulates express... |
| _timestamp | 2022-01-16 15:25:36 |
| created | [InstanceEdit:9761879] Rothfels, Karen, 2022-01-16 |
| modified | [InstanceEdit:9761914] Rothfels, Karen, 2022-01-16 |
| text | Chronic hepatitis B virus (HBV) infection stimulates expression of glucose-6-phosphate dehydrogenase (G6PD), the enzyme that catalyzes the first step of the pentose phosphate pathway (PPP). HBV-stimulated G6PD expression depends upon activation of the NFE2L2 pathway through sequestration of the KEAP1 negative regulator of NFE2L2. HBV X protein interacts with SQSTM1, also known as p62, and stimulates formation of an X:SQSTM1:KEAP1 complex. This complex disrupts the KEAP1-dependent ubiquitination of NFE2L2, stabilizing the transcription factor and allowing it to translocate to the nucleus to stimulate expression of target genes including G6PD (Liu et al, 2017; reviewed in Baird and Yamamoto, 2020; Bender and Hildt, 2019). |
| (summation) | [Reaction:9761900] HBV X protein binds SQSTM1 oligomer [Homo sapiens] |
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No pathways have been reviewed or authored by Chronic hepatitis B virus (HBV) infection stimulates express... (9761878)
