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Details on Person AcK-NFE2L2-dependent P6GD gene expression

Class:Id	BlackBoxEvent:9761849
_displayName	AcK-NFE2L2-dependent P6GD gene expression
_doRelease	TRUE
_timestamp	2022-02-28 16:32:05
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9761842] Rothfels, Karen, 2022-01-15
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[EntityWithAccessionedSequence:9761730] G6PD gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761654] The Role of the Pentose Phosphate Pathway in Diabetes and Cancer [LiteratureReference:9761640] Oxidative Stress in Cancer [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9759273] Beneficial role of Nrf2 in regulating NADPH generation and consumption [LiteratureReference:9761612] Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks [LiteratureReference:9761603] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
modified	[InstanceEdit:9767068] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK-NFE2L2-dependent P6GD gene expression
output	[DefinedSet:464971] G6PD dimer and tetramer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9761812] AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD [Homo sapiens] [Reaction:9760081] CREBBP, EP300 acetylates NFE2L2 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9761855] Positive gene expression regulation by 'G6PD gene:p-AcK-NFE2L2:CREBBP,EP300:MAFG [nucleoplasm]'
regulationReference	[RegulationReference:9761853] Positive gene expression regulation by 'P6GD gene:p-AcK-NFE2L2:CREBBP,EP300:MAFG [nucleoplasm]' Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9761868] R-HSA-9761849.2
summation	[Summation:9761770] Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the first...
(hasEvent)	[Pathway:9818028] NFE2L2 regulates pentose phosphate pathway genes [Homo sapiens]
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No pathways have been reviewed or authored by AcK-NFE2L2-dependent P6GD gene expression (9761849)