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Details on Person NFE2L2-dependent PGD gene expression

Class:Id	BlackBoxEvent:9761846
_displayName	NFE2L2-dependent PGD gene expression
_doRelease	TRUE
_timestamp	2022-02-28 16:33:23
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9761842] Rothfels, Karen, 2022-01-15
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[EntityWithAccessionedSequence:8957562] PGD gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761654] The Role of the Pentose Phosphate Pathway in Diabetes and Cancer [LiteratureReference:9761640] Oxidative Stress in Cancer [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9759273] Beneficial role of Nrf2 in regulating NADPH generation and consumption [LiteratureReference:9761603] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming [LiteratureReference:9761675] The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells
modified	[InstanceEdit:9767043] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767534] Rothfels, Karen, 2022-02-28 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFE2L2-dependent PGD gene expression
output	[Complex:467365] PGD dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9761828] NFE2L2 binds the PGD gene [Homo sapiens] [BlackBoxEvent:8932309] NFE2L2 translocates from cytosol to nucleoplasm [Homo sapiens] [Reaction:9760081] CREBBP, EP300 acetylates NFE2L2 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9761847] Positive gene expression regulation by 'PGD gene:p-AcK NFE2L2:CREBBP,EP300:MAFG [nucleoplasm]'
regulationReference	[RegulationReference:9761839] Positive gene expression regulation by 'PGD gene:p-NFE2L2 [nucleoplasm]' The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9761866] R-HSA-9761846.2
summation	[Summation:9761783] Phosphogluconate 6-dehydrogenase catalyzes the third step of...
(hasEvent)	[Pathway:9818028] NFE2L2 regulates pentose phosphate pathway genes [Homo sapiens]
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No pathways have been reviewed or authored by NFE2L2-dependent PGD gene expression (9761846)