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Details on Person NFE2L2-dependent IDH1 gene expression

Class:Id	BlackBoxEvent:9761844
_displayName	NFE2L2-dependent IDH1 gene expression
_doRelease	TRUE
_timestamp	2022-02-28 16:33:19
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9761842] Rothfels, Karen, 2022-01-15
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[EntityWithAccessionedSequence:8958018] IDH1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761580] IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives [LiteratureReference:9761658] The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism [LiteratureReference:9761603] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9761640] Oxidative Stress in Cancer
modified	[InstanceEdit:9762212] Rothfels, Karen, 2022-01-18 [InstanceEdit:9767041] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFE2L2-dependent IDH1 gene expression
output	[Complex:389559] IDH1 dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9761822] NFE2L2 binds the IDH1 gene [Homo sapiens] [BlackBoxEvent:8932309] NFE2L2 translocates from cytosol to nucleoplasm [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9761857] Positive gene expression regulation by 'IDH1 gene:p-NFE2L2 [nucleoplasm]'
regulationReference	[RegulationReference:9761848] Positive gene expression regulation by 'IDH1 gene:p-NFE2L2 [nucleoplasm]' Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9761870] R-HSA-9761844.2
summation	[Summation:9761794] The IDH1 gene encodes the cytosolic NADP-dependent isocitrat...
(hasEvent)	[Pathway:9818025] NFE2L2 regulating TCA cycle genes [Homo sapiens]
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No pathways have been reviewed or authored by NFE2L2-dependent IDH1 gene expression (9761844)