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Details on Person NFE2L2-dependent GSR gene expression

Class:Id	BlackBoxEvent:9761843
_displayName	NFE2L2-dependent GSR gene expression
_doRelease	TRUE
_timestamp	2022-02-28 16:33:12
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9761842] Rothfels, Karen, 2022-01-15
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[EntityWithAccessionedSequence:9761721] GSR gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761621] Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
modified	[InstanceEdit:9762129] Rothfels, Karen, 2022-01-17 [InstanceEdit:9767038] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFE2L2-dependent GSR gene expression
output	[Complex:71680] GSR-2:FAD dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9761818] NFE2L2 binds the GSR gene [Homo sapiens] [BlackBoxEvent:8932309] NFE2L2 translocates from cytosol to nucleoplasm [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9761845] Positive gene expression regulation by 'GSR gene:p-NFE2L2 [nucleoplasm]'
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9761865] R-HSA-9761843.2
summation	[Summation:9761771] Glutathione reductase (GSR) contributes to the redox balance...
(hasEvent)	[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
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No pathways have been reviewed or authored by NFE2L2-dependent GSR gene expression (9761843)