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Details on Person AcK-NFE2L2-dependent SLC7A11 expression

Class:Id	BlackBoxEvent:9761841
_displayName	AcK-NFE2L2-dependent SLC7A11 expression
_doRelease	TRUE
_timestamp	2022-02-28 16:32:07
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9761842] Rothfels, Karen, 2022-01-15
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[EntityWithAccessionedSequence:9761709] SLC7A11 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761660] The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities [LiteratureReference:9761568] Cellular degradation systems in ferroptosis [LiteratureReference:9761634] Oxidative Damage and Antioxidant Defense in Ferroptosis [LiteratureReference:9761641] Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9708514] Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages [LiteratureReference:9761571] Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression [LiteratureReference:9761593] NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression [LiteratureReference:9761600] Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1 [LiteratureReference:9761606] Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition
modified	[InstanceEdit:9767005] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK-NFE2L2-dependent SLC7A11 expression
output	[EntityWithAccessionedSequence:378515] SLC7A11 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9761815] AcK-NFE2L2 and ATF4 bind the SLC7A11 gene [Homo sapiens] [Reaction:9760081] CREBBP, EP300 acetylates NFE2L2 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9761851] Positive gene expression regulation by 'SLC7A11 gene:p-AcK-NFE2L2:ATF4 [nucleoplasm]'
regulationReference	[RegulationReference:9761856] Positive gene expression regulation by 'SLC7A11 gene:p-AcK-NFE2L2:ATF4 [nucleoplasm]' NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9761867] R-HSA-9761841.2
summation	[Summation:9761787] SLC7A11 encodes one component of system xc-, a heterodimeric...
(hasEvent)	[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
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No pathways have been reviewed or authored by AcK-NFE2L2-dependent SLC7A11 expression (9761841)