Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NFE2L2 binds the ME1 gene

Class:IdReaction:9761825
_displayNameNFE2L2 binds the ME1 gene
_doReleaseTRUE
_timestamp2022-02-28 16:32:58
authored[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9761824] Rothfels, Karen, 2022-01-15
edited[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input[EntityWithAccessionedSequence:5649931] ME1 gene [nucleoplasm] [Homo sapiens]
[CandidateSet:9708562] p-NFE2L2 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9761587] Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism
[LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
[LiteratureReference:9759273] Beneficial role of Nrf2 in regulating NADPH generation and consumption
[LiteratureReference:9761603] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
[LiteratureReference:9761654] The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
[LiteratureReference:9761633] Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism
modified[InstanceEdit:9767030] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNFE2L2 binds the ME1 gene
output[Complex:9761753] ME1 gene:p-NFE2L2 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2022-03-23
reviewed[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9761826] R-HSA-9761825.2
summation[Summation:9761777] ME1 encodes the cytosolic NADP-dependent malic enzyme, which...
(hasEvent)[Pathway:9818025] NFE2L2 regulating TCA cycle genes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9761854] NFE2L2-dependent ME1 gene expression [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by NFE2L2 binds the ME1 gene (9761825)