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Details on Person AcK-NFE2L2 and ATF4 bind the SLC7A11 gene

Class:IdReaction:9761815
_displayNameAcK-NFE2L2 and ATF4 bind the SLC7A11 gene
_doReleaseTRUE
_timestamp2022-02-28 16:31:43
authored[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9761816] Rothfels, Karen, 2022-01-15
edited[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input[EntityWithAccessionedSequence:9761709] SLC7A11 gene [nucleoplasm] [Homo sapiens]
[Complex:9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:381016] ATF4 [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9761660] The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities
[LiteratureReference:9761568] Cellular degradation systems in ferroptosis
[LiteratureReference:9761634] Oxidative Damage and Antioxidant Defense in Ferroptosis
[LiteratureReference:9761641] Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators
[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
[LiteratureReference:9708514] Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
[LiteratureReference:9761606] Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition
[LiteratureReference:9761571] Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
[LiteratureReference:9761593] NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
[LiteratureReference:9761600] Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1
modified[InstanceEdit:9766995] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAcK-NFE2L2 and ATF4 bind the SLC7A11 gene
output[Complex:9761741] SLC7A11 gene:p-AcK-NFE2L2:ATF4 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2022-03-23
reviewed[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9761817] R-HSA-9761815.2
summation[Summation:9761790] SLC7A11 encodes one component of system xc-, a heterodimeric...
(hasEvent)[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9761841] AcK-NFE2L2-dependent SLC7A11 expression [Homo sapiens]
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No pathways have been reviewed or authored by AcK-NFE2L2 and ATF4 bind the SLC7A11 gene (9761815)
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