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Details on Person AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD

Class:Id	Reaction:9761812
_displayName	AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD
_doRelease	TRUE
_timestamp	2022-02-28 16:31:41
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9761813] Rothfels, Karen, 2022-01-15
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
inferredFrom	[Reaction:9761809] Nfe2l2, Mafg and Creb1 bind the G6pdx gene [Mus musculus]
input	[EntityWithAccessionedSequence:9761730] G6PD gene [nucleoplasm] [Homo sapiens] [Complex:9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1008212] MAFG [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9761640] Oxidative Stress in Cancer [Book:9762038] Lin, Tin-Yu NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2 [LiteratureReference:9761654] The Role of the Pentose Phosphate Pathway in Diabetes and Cancer [LiteratureReference:9761645] The Complex Interplay between Antioxidants and ROS in Cancer [LiteratureReference:9759273] Beneficial role of Nrf2 in regulating NADPH generation and consumption [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9761603] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming [LiteratureReference:9761612] Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks [LiteratureReference:9761694] c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation
modified	[InstanceEdit:9762111] Rothfels, Karen, 2022-01-17 [InstanceEdit:9766994] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD
output	[Complex:9761748] G6PD gene:p-AcK-NFE2L2:CREBBP,EP300:MAFG [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9760081] CREBBP, EP300 acetylates NFE2L2 [Homo sapiens] [Reaction:9760082] NFE2L2 binds CREBBP,EP300 [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9761814] R-HSA-9761812.2
summation	[Summation:9761765] Cytosolic glucose-6-phosphate dehydrogenase (G6PD) catalyzes...
(hasEvent)	[Pathway:9818028] NFE2L2 regulates pentose phosphate pathway genes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9761849] AcK-NFE2L2-dependent P6GD gene expression [Homo sapiens]
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No pathways have been reviewed or authored by AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD (9761812)