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Details on Person The IDH1 gene encodes the cytosolic NADP-dependent isocitrat...
| Class:Id | Summation:9761794 |
|---|---|
| _displayName | The IDH1 gene encodes the cytosolic NADP-dependent isocitrat... |
| _timestamp | 2022-01-18 20:51:45 |
| created | [InstanceEdit:9761793] Rothfels, Karen, 2022-01-15 |
| modified | [InstanceEdit:9762212] Rothfels, Karen, 2022-01-18 |
| text | The IDH1 gene encodes the cytosolic NADP-dependent isocitrate dehydrogenase, which catalyzes the reversible conversion of isocitrate to 2-oxoglutarate, generating NADPH. IDH1 is thus a key player in maintaining the redox and metabolic balance in the cell and has been shown to be dysregulated in many cancers (reviewed in Mondesir et al, 2016; Chang et al, 2019). IDH1 expression is regulated downstream of the KEAP1-NFE2L2 pathway and has been shown to be a direct target of NFE2L2 (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020; Hayes et al, 2020). |
| (summation) | [BlackBoxEvent:9761844] NFE2L2-dependent IDH1 gene expression [Homo sapiens] |
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No pathways have been reviewed or authored by The IDH1 gene encodes the cytosolic NADP-dependent isocitrat... (9761794)
