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Details on Person Phosphogluconate dehydrogenase (PGD, also known as 6PGDH) is...
| Class:Id | Summation:9761786 |
|---|---|
| _displayName | Phosphogluconate dehydrogenase (PGD, also known as 6PGDH) is... |
| _timestamp | 2022-01-18 20:51:39 |
| created | [InstanceEdit:9761785] Rothfels, Karen, 2022-01-15 |
| modified | [InstanceEdit:9762212] Rothfels, Karen, 2022-01-18 |
| text | Phosphogluconate dehydrogenase (PGD, also known as 6PGDH) is an enzyme involved in the pentose phosphate pathway (PPP). The PPP is an alternative glucose metabolism pathway that branches off from glycolysis, consuming the shared metabolite glucose-6-phosphate to produce fructose-6-phosphate and glyceraldehyde-3-phosphate in the oxidative and non-oxidative branches, respectively. The PPP generates NADPH in place of ATP and is a source of biosynthetic intermediates required for nucleic acid, fatty acid and amino acid generation. Cells may switch to the PPP to support phases of highly proliferative growth, and also as a response to oxidative stress (reviewed in Ge et al, 2020; Hayes et al, 2020). PGD catalyzes the third step of the oxidative branch of the PPP, the conversion of 6-phosphogluconate to ribulose-5-phosphate (Ru5P), and simultaneously generates NADPH. Ru5P is an intermediate on the synthetic pathway for nucleic acids and NADPH contributes reducing power needed for the synthesis of fatty acids, nucleotides and non-essential amino acids. PGD expression is regulated in part by the binding of NFE2L2 and MAFG to the antioxidant response element (ARE) in the promoter (Ong et al, 2020; Mitsuishi et al, 2012; Hirotsu et al, 2012). CREBBP is also recruited to the PDG promoter in response to treatment of mouse cells with the NFE2L2 inducer diethyl maleate (DEM), and is associated with acquistion of histone modifications indicative of transcriptional activation (Hirotsu et al, 2012). Although recruitment of CREBBP/EP300 with NFE2L2 has been associated with NFE2L2 acetylation at other target gene promoters, this has not been directly demonstrated in the case of the PGD gene (Sun et al, 2009). Keap1-NFE2L2-dependent regulation of PGD contributes to metabolic reprogramming during initiation of cancer as well as to the response to oxidative stress (Thimmaluppa et al, 2002; Wu et al, 2011; reviewed in Baird and Yamamoto, 2020; Ge et al, 2020; Hayes et al, 2020). |
| (summation) | [Reaction:9761828] NFE2L2 binds the PGD gene [Homo sapiens] |
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