Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person ME1 encodes the cytosolic NADP-dependent malic enzyme, which...
| Class:Id | Summation:9761777 |
|---|---|
| _displayName | ME1 encodes the cytosolic NADP-dependent malic enzyme, which... |
| _timestamp | 2022-01-15 22:52:57 |
| created | [InstanceEdit:9761778] Rothfels, Karen, 2022-01-15 |
| text | ME1 encodes the cytosolic NADP-dependent malic enzyme, which converts malate to pyruvate, generating NADPH. Through the generation of NADPH, ME1 contributes to the redox balance of the cell as well as playing a key role in lipid and cholesterol biosynthesis. ME1 links the citric acid cycle and glycolysis through the interconversion of pyruvate and malate and also play a role in the Warburg effect (reviewed in Simmen et al, 2020). ME1 has been shown to be a NFE2L2-responsive gene (Thimmulappa et al, 2002; Wu et al, 2011) and NFE2L2 binds directly to the anti-oxidant response element (ARE) in the ME1 promoter as assessed by ChIP-seq (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020; Smolkova et al, 2020; Ge et al, 2020) |
| (summation) | [Reaction:9761825] NFE2L2 binds the ME1 gene [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by ME1 encodes the cytosolic NADP-dependent malic enzyme, which... (9761777)
