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Details on Person Activated ubiquitin is transferred from E1 to the active sit...
| Class:Id | Summation:976170 |
|---|---|
| _displayName | Activated ubiquitin is transferred from E1 to the active sit... |
| _timestamp | 2010-10-29 15:33:24 |
| created | [InstanceEdit:976167] Garapati, P V, 2010-10-11 |
| literatureReference | [LiteratureReference:982833] The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction |
| modified | [InstanceEdit:982835] Garapati, P V, 2010-10-29 [InstanceEdit:983177] Jupe, S, 2010-10-29 |
| text | Activated ubiquitin is transferred from E1 to the active site cystine of ubiquitin conjugating enzymes (E2s) via a trans-esterification reaction. E2s catalyze covalent attachment of ubiquitin to target proteins. They all share an active-site ubiquitin-binding cysteine residue and are distinguished by the presence of a ubiquitin-conjugating catalytic (UBC) fold required for binding of distinct ubiquitin ligases or E3s. Once conjugated to ubiquitin, the E2 molecule binds one of several E3s (Glickman et al. 2002). |
| (summation) | [Reaction:983152] Transfer of ubiquitin from E1 to E2 [Homo sapiens] |
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No pathways have been reviewed or authored by Activated ubiquitin is transferred from E1 to the active sit... (976170)
