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Details on Person Angiomotin (AMOT) isoform p80 (AMOT-2) binds to CDH11 C-term...
| Class:Id | Summation:9761489 |
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| _displayName | Angiomotin (AMOT) isoform p80 (AMOT-2) binds to CDH11 C-term... |
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| _timestamp | 2022-06-09 20:29:26 |
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| created | [InstanceEdit:9761483] Orlic-Milacic, Marija, 2022-01-14 |
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| literatureReference | [LiteratureReference:9761439] Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration
[LiteratureReference:9761481] Angiomotin expression promotes hemangioendothelioma invasion
[LiteratureReference:9761485] Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer
[LiteratureReference:9761496] A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions
[LiteratureReference:9761525] Impact of Detergents on Membrane Protein Complex Isolation |
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| modified | [InstanceEdit:9761544] Orlic-Milacic, Marija, 2022-01-14
[InstanceEdit:9793104] Orlic-Milacic, Marija, 2022-06-02
[InstanceEdit:9793237] Orlic-Milacic, Marija, 2022-06-09 |
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| text | Angiomotin (AMOT) isoform p80 (AMOT-2) binds to CDH11 C-terminal binding sequence (CBS). The CBS motif of CDH11 that binds AMOT-2 does not overlap with the CBS motif that binds CTNNB1 (beta-catenin). The two CBS motifs are 40 amino acid residues apart, but it is uncertain if there is any steric hindrance between simultaneous binding of CTNNB1 and AMOT-2 to CDH11. AMOT-2 binding to CDH11 appears to stimulate CDH11-mediated cell migration. AMOT-2 has been implicated as a promoter of tumorigenesis in previous studies (Levchenko et al. 2004; Jiang et al. 2006; Yi et al. 2011, Ortiz et al. 2015). AMOT was identified as a CDH11 interactor in the high-throughput screen conducted by Lee et al. 2018. |
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| (summation) | [Reaction:9761474] AMOT-2 binds CDH11 [Homo sapiens] |
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No pathways have been reviewed or authored by Angiomotin (AMOT) isoform p80 (AMOT-2) binds to CDH11 C-term... (9761489)
