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Details on Person The co-localization of endogenous mouse Ctnna1(alpha-catenin...
| Class:Id | Summation:9761460 |
|---|---|
| _displayName | The co-localization of endogenous mouse Ctnna1(alpha-catenin... |
| _timestamp | 2022-06-02 15:04:47 |
| created | [InstanceEdit:9761462] Orlic-Milacic, Marija, 2022-01-14 |
| modified | [InstanceEdit:9793103] Orlic-Milacic, Marija, 2022-06-02 |
| text | The co-localization of endogenous mouse Ctnna1(alpha-catenin), in the mouse L cells (a fibroblast cell line), with exogenously expressed human CDH11 at the plasma membrane is dependent on the presence of the C-terminal binding sequence (CBS), involved in CTNNB1 (beta-catenin) binding (Kiener et al. 2006). While the presence of the juxtamembrane domain (JMD) of CDH11, which binds CTNND1 (p120 catenin, also known as delta-catenin), is not needed for the recruitment of Ctnna1, the JMD of CDH11 was shown to regulate Ctnna1 turnover at adherens junctions. The rate of Ctnna1 turnover is decreased in cells expressing CDH11 that lacks the JMD, which is thought to lead to formation of a more extensive cortical F-actin ring and an increased level of activated Rac1 (Kiener et al. 2006). |
| (summation) | [Reaction:9761463] Ctnna1 binds to CDH11-bound Ctnnb1 [Homo sapiens] |
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