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Details on Person Cadherin-bound CTNNB1 (beta-catenin) at the plasma membrane ...
| Class:Id | Summation:9761448 |
|---|---|
| _displayName | Cadherin-bound CTNNB1 (beta-catenin) at the plasma membrane ... |
| _timestamp | 2022-06-09 20:29:28 |
| created | [InstanceEdit:9761454] Orlic-Milacic, Marija, 2022-01-14 |
| literatureReference | [LiteratureReference:9761436] The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility [LiteratureReference:9761453] Molecular organization of the uvomorulin-catenin complex [LiteratureReference:9761499] A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells [LiteratureReference:9761513] The organization of adherens junctions in mouse osteoblast-like cells (MC3T3-E1) and their modulation by triiodothyronine and 1,25-dihydroxyvitamin D3 [LiteratureReference:9761525] Impact of Detergents on Membrane Protein Complex Isolation [LiteratureReference:9762166] A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin [LiteratureReference:9762171] Assembly of the cadherin-catenin complex in vitro with recombinant proteins [LiteratureReference:9762176] Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion |
| modified | [InstanceEdit:9761508] Orlic-Milacic, Marija, 2022-01-14 [InstanceEdit:9761509] Orlic-Milacic, Marija, 2022-01-14 [InstanceEdit:9761516] Orlic-Milacic, Marija, 2022-01-14 [InstanceEdit:9762168] Orlic-Milacic, Marija, 2022-01-17 [InstanceEdit:9762175] Orlic-Milacic, Marija, 2022-01-17 [InstanceEdit:9762178] Orlic-Milacic, Marija, 2022-01-17 [InstanceEdit:9793102] Orlic-Milacic, Marija, 2022-06-02 [InstanceEdit:9793237] Orlic-Milacic, Marija, 2022-06-09 |
| text | Cadherin-bound CTNNB1 (beta-catenin) at the plasma membrane is known to associate with CTNNA1 (alpha-catenin) through the N-terminal domain of beta-catenin (Ozawa and Kemler 1992). CTNNA1 was shown to be a part of the complex of CDH11, CTNND1 and CTNNB1 in the cortex adherens structure formed by the eye lens fiber cells in all three organisms tested: cow, pig and rat (Straub et al. 2003). The co-localization of CTNNA1 with CDH11 at the plasma membrane is dependent on the presence of the C-terminal binding sequence (CBS), involved in CTNNB1 binding (Kiener et al. 2006). While the presence of the juxtamembrane domain (JMD) of CDH11, which binds CTNND1 (p120 catenin, also known as delta-catenin) is not needed for the recruitment of CTNNA1, the JMD of CDH11 was shown to regulate CTNNA1 turnover at adherens junctions. The rate of CTNNA1 turnover is decreased in cells expressing CDH11 that lacks the JMD, leading to formation of a more extensive cortical F actin ring and an increased level of activated RAC1 (Kiener et al. 2006). Binding of CTNNA1 to cadherin-associated CTNNB1 may be mutually exclusive with binding of vinculin (VCL) (Luegmayr et al. 2000). Based on studies with other cadherins, CTNNA1 can also be recruited to cadherins through association with JUP (Junctional Plakoglobin, also known as gamma-catenin) (Butz and Kemler 1994; Aberle et al. 1994; Huber et al. 1997), which is known to be an interaction partner of CDH11 (Lee et al. 2018). |
| (summation) | [Reaction:9761452] CTNNA1 binds to CDH11-bound CTNNB1 [Homo sapiens] |
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No pathways have been reviewed or authored by Cadherin-bound CTNNB1 (beta-catenin) at the plasma membrane ... (9761448)
