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Details on Person CDH11 gene is transcribed into nascent CDH11 mRNA

Class:Id	BlackBoxEvent:9760965
_displayName	CDH11 gene is transcribed into nascent CDH11 mRNA
_doRelease	TRUE
_timestamp	2023-05-13 14:32:13
authored	[InstanceEdit:9793111] Orlic-Milacic, Marija, 2022-06-02
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9760966] Orlic-Milacic, Marija, 2022-01-05
edited	[InstanceEdit:9833282] Orlic-Milacic, Marija, 2023-04-19
inferredFrom	[BlackBoxEvent:9761140] Transcription of Cdh11 gene is repressed by Bhlhe22 and Prdm8 [Mus musculus]
input	[EntityWithAccessionedSequence:9759494] CDH11 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9760626] HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression [LiteratureReference:9760400] Interleukin enhancer-binding factor 3 and HOXC8 co-activate cadherin 11 transcription to promote breast cancer cells proliferation and migration [LiteratureReference:9760632] Identification of a Hoxc8-regulated transcriptional network in mouse embryo fibroblast cells [LiteratureReference:9761033] ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression [LiteratureReference:9761051] Charactering tumor microenvironment reveals stromal-related transcription factors promote tumor carcinogenesis in gastric cancer [LiteratureReference:9761064] FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts [LiteratureReference:9761153] TGF-β1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation [LiteratureReference:9760636] The identification of Hoxc8 target genes
modified	[InstanceEdit:9761019] Orlic-Milacic, Marija, 2022-01-06 [InstanceEdit:9761042] Orlic-Milacic, Marija, 2022-01-06 [InstanceEdit:9761058] Orlic-Milacic, Marija, 2022-01-06 [InstanceEdit:9761079] Orlic-Milacic, Marija, 2022-01-06 [InstanceEdit:9761080] Orlic-Milacic, Marija, 2022-01-06 [InstanceEdit:9761123] Orlic-Milacic, Marija, 2022-01-07 [InstanceEdit:9761146] Orlic-Milacic, Marija, 2022-01-10 [InstanceEdit:9761159] Orlic-Milacic, Marija, 2022-01-10 [InstanceEdit:9793092] Orlic-Milacic, Marija, 2022-06-02 [InstanceEdit:9793119] Orlic-Milacic, Marija, 2022-06-02 [InstanceEdit:9833282] Orlic-Milacic, Marija, 2023-04-19 [InstanceEdit:9833283] Orlic-Milacic, Marija, 2023-04-19 [InstanceEdit:9835200] Matthews, Lisa, 2023-05-12 [InstanceEdit:9835376] Orlic-Milacic, Marija, 2023-05-13 [InstanceEdit:9835794] Matthews, Lisa, 2023-05-17
name	CDH11 gene is transcribed into nascent CDH11 mRNA
output	[EntityWithAccessionedSequence:9760967] CDH11 nascent mRNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9760641] HOXC8 binds CDH11 gene promoter [Homo sapiens] [Reaction:9760399] ILF3 and HOXC8 bind CDH11 gene promoter [Homo sapiens] [Reaction:9760402] ILF3 binds HOXC8 [Homo sapiens] [Reaction:9760652] ILF3 binds CDH11 gene promoter [Homo sapiens] [Reaction:9761025] ZEB2 and SP1 bind CDH11 gene promoter [Homo sapiens] [Reaction:9761027] ZEB2 binds SP1 [Homo sapiens] [Reaction:9761047] HEYL binds CDH11 gene promoter [Homo sapiens] [Reaction:9761065] FOXF1 binds CDH11 gene promoter [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9760650] Positive gene expression regulation by 'ILF3:HOXC8:CDH11 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9760649] Positive gene expression regulation by 'HOXC8:CDH11 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9760656] Positive gene expression regulation by 'ILF3:CDH11 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9761041] Positive gene expression regulation by 'ZEB2:SP1:CDH11 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9761052] Positive gene expression regulation by 'HEYL:CDH11 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9761063] Negative gene expression regulation by 'FOXF1:CDH11 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9761119] Negative gene expression regulation by 'PRDM8:BHLHE22 homodimer:CDH11 gene [nucleoplasm]' [PositiveRegulation:9761150] Positive regulation by 'SNAI1 [nucleoplasm]'
releaseDate	2023-06-07
reviewed	[InstanceEdit:9833280] Brasch, Julia, 2023-04-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9760969] R-HSA-9760965.1
summation	[Summation:9761017] Transcription of the CDH11 gene is governed by several trans...
(hasEvent)	[Pathway:9762293] Regulation of CDH11 gene transcription [Homo sapiens]
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No pathways have been reviewed or authored by CDH11 gene is transcribed into nascent CDH11 mRNA (9760965)