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Details on Person E. coli heat-labile enterotoxin (LT) is secreted from the pe...
| Class:Id | Summation:9760832 |
|---|---|
| _displayName | E. coli heat-labile enterotoxin (LT) is secreted from the pe... |
| _timestamp | 2024-07-04 08:26:58 |
| created | [InstanceEdit:9760833] Stephan, Ralf, 2022-01-04 |
| modified | [InstanceEdit:9912369] Stephan, Ralf, 2024-06-08 [InstanceEdit:9915279] Stephan, Ralf, 2024-07-04 |
| text | E. coli heat-labile enterotoxin (LT) is secreted from the periplasm by the type II secretion system (T2SS) (Tauschek et al, 2002; Mudrak & Kuehn, 2010; Reichow et al, 2011; Horstman & Kuehn, 2012; Lu et al, 2016). The main and characteristic part of the T2SS in double-walled prokaryotes is a transporter complex that spans from the plasma membrane to the cell outer membrane. Its structural core consists of the anchor GspC2, located on the periplasmic side of the plasma membrane, bound to the outer membrane secretin, a pore complex consisting of fifteen units of GspD2 and fifteen units of GspS2. For the moving parts, T2SS has been proposed to assemble a filamentous structure termed “pseudopilus” to push exoproteins through the secretin channel, acting as a piston (Nivaskumar & Francetic, 2014; Yin et al, 2018). |
| (summation) | [Reaction:9760705] GspD2:GspC2:GspS2 transports LT from periplasmic to extracellular space [Homo sapiens] |
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