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Details on Person UniProt:E3PJ88 gspS2
| Class:Id | ReferenceGeneProduct:9760716 |
|---|---|
| _chainChangeLog | signal peptide:1-24 for 9760716 added on Fri February 25 2022;chain:25-136 for 9760716 added on Fri February 25 2022 |
| _displayName | UniProt:E3PJ88 gspS2 |
| _timestamp | 2025-05-21 21:35:09 |
| chain | signal peptide:1-24 chain:25-136 |
| checksum | 8CF2819C427D869A |
| comment | FUNCTION Part of a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane (Probable). Required for correct assembly of the type II secretion system-beta (T2SS-beta), for localization of GspD-beta to the cell outer membrane and for export of a labile enterotoxin by T2SS-beta (PubMed:22585966). Each AspS2 binds to 2 GspD2 subunits and may clamp the monomers together, stabilizing structure and accelerating its assembly (PubMed:29632366).SUBUNIT Cryo-electron microscopy shows that the complex forms a cylindrical channel with 15 GspD2 subunits, each of which interacts with its surrounding AspS2 (GspS-beta).SUBCELLULAR LOCATION Protein can also be located in the cell inner membrane.DISRUPTION PHENOTYPE Severely disrupts assembly and function of T2SS-beta, mislocalization of GspD-beta to the cell inner membrane.MISCELLANEOUS Encoded in a type II secretion system (T2SS-beta); this strain encodes 2 T2SS but only this one (beta) is expressed under standard laboratory conditions.SIMILARITY Belongs to the GspS/AspS pilotin family. |
| created | [InstanceEdit:9760696] Stephan, Ralf, 2021-12-22 |
| description | recommendedName: fullName evidence="5"Pilotin AspS 2 alternativeName: fullName evidence="4"Type II secretion system-beta protein GspS-beta |
| geneName | gspS2 aspS gspS-beta yghG ETEC_3239 |
| identifier | E3PJ88 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell outer membrane Disulfide bond Lipoprotein Membrane Palmitate Signal |
| modified | [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | gspS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ASPS2_ECOH1 |
| sequenceLength | 136 |
| species | [Species:9760713] Escherichia coli O78:H11 |
| (referenceEntity) | [EntityWithAccessionedSequence:9760690] GspS2 [cell outer membrane] [Escherichia coli O78:H11] |
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No pathways have been reviewed or authored by UniProt:E3PJ88 gspS2 (9760716)
