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Details on Person La-related protein 1 (LARP1) binds the 7-methylguanosine tri...
| Class:Id | Summation:9760489 |
|---|---|
| _displayName | La-related protein 1 (LARP1) binds the 7-methylguanosine tri... |
| _timestamp | 2022-03-02 14:47:25 |
| created | [InstanceEdit:9760447] Shamovsky, Veronica, 2021-12-18 |
| literatureReference | [LiteratureReference:9760431] La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs [LiteratureReference:9760461] Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation [LiteratureReference:9760513] mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 [LiteratureReference:9760465] LARP1 specifically recognizes the 3' terminus of poly(A) mRNA [LiteratureReference:9760487] The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1 [LiteratureReference:9760482] The LARP1 La-Module recognizes both ends of TOP mRNAs [LiteratureReference:9760466] LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs [LiteratureReference:9760426] Controversies around the function of LARP1 [LiteratureReference:9760423] La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1) [LiteratureReference:9760458] Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5' TOP motifs [LiteratureReference:9760485] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions [LiteratureReference:9760467] The SARS-CoV-2 RNA interactome [LiteratureReference:9760305] The SARS-CoV-2 RNA-protein interactome in infected human cells |
| modified | [InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767957] Shamovsky, Veronica, 2022-03-02 |
| text | La-related protein 1 (LARP1) binds the 7-methylguanosine triphosphate (m7Gppp) cap and adjacent 5’-terminal oligopyrimidine (5’TOP) motif of 5'TOP-bearing mRNAs that encode components of ribosome biogenesis (Tcherkezian J et al. 2014; Lahr RM et al. 2017). LARP1 can also bind to 3' terminus of poly(A) mRNA (Aoki K et al. 2013; Mattijssen S et al. 2021; Al-Ashtal HA et al. 2021). LARP1 regulates 5'TOP mRNA translation downstream of mTOR complex 1 (mTORC1) thus linking mTORC1 signalling to ribosome biogenesis (Fonseca BD et al. 2015; Tcherkezian J et al. 2014; Hong S et al. 2015; Lahr RM et al. 2017). Upon mTORC1 inhibition LARP1 has increased affinity for 5′TOP mRNAs (Fonseca BD et al. 2015), whereas mTORC1-mediated phosphorylation of LARP1 impairs RNA binding and regulatory function of LARP1 (Hong S et al. 2015; Jia JJ et al. 2021). LARP1 regulates 5'TOP mRNA translation via the C-terminal DM15 region (Lahr RM et al. 2017). It remains controversial whether LARP1 functions as a translation repressor (Fonseca BD et al. 2015; Lahr RM et al. 2017; Philippe L et al. 2018, 2020) or stabilizer of 5'TOP mRNAs (Aoki K et al. 2013; Tcherkezian J et al. 2014; reviewed in Berman AJ et al. 2021). As an RNA-binding protein LARP1 was identified in the interactome of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) RNA (Schmidt N et al. 2021; Lee S et al. 2021; Flynn RA et al. 2021). Enhanced crosslinking and immunoprecipitation (eCLIP) data suggest that LARP1 may interact with pyrimidine-rich sites within SARS-CoV-2 RNA (Schmidt N et al. 2021). LARP1 deficiency in SARS-CoV-2-infected human embryonic kidney (HEK293) cells and human lung cancer (Calu-3) cells resulted in elevated levels of intracellular viral RNA (Schmidt N et al. 2021; Lee S et al. 2021). Contrarily, overexpression of LARP1 led to a reduction of viral growth. These data suggest that LARP1 functions as an antiviral host factor (Schmidt N et al. 2021; Lee S et al. 2021). This Reactome event shows LARP1 binding to SARS-CoV-2 5'RNA. |
| (summation) | [Reaction:9760510] LARP1 binds SARS-CoV-2 RNA [Homo sapiens] |
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