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Details on Person In mesendoderm progenitors, Foxh1 and Smad3 are pre-bound to...
| Class:Id | Summation:9760361 |
|---|---|
| _displayName | In mesendoderm progenitors, Foxh1 and Smad3 are pre-bound to... |
| _timestamp | 2022-07-25 06:32:22 |
| created | [InstanceEdit:9760358] May, Bruce, 2021-12-16 |
| modified | [InstanceEdit:9760419] May, Bruce, 2021-12-18 [InstanceEdit:9794984] May, Bruce, 2022-07-25 |
| text | In mesendoderm progenitors, Foxh1 and Smad3 are pre-bound to the Gsc gene (Aragon et al. 2019). Nodal signaling causes phosphorylation of Smad2 and Smad3, which bind Smad4, transit to the nucleus and interact with Smad3 at the Gsc promoter (Wang et al. 2017, Aragon et al. 2019). Eomes also binds regulatory regions of the Gsc gene and is crucial for its activation (Teo et al. 2011, Tosic et al. 2019). A Tcf binding element (bound by Tcf3) in a Smad2,3 bound enhancer is also important for proper Gsc expression (Wang et al. 2017). After activation by Nodal, phosphorylated Smad2 and Smad3 are also complexed with Trim33 in the nucleus and the p-2S-Smad2,3:Trim33 complex binds the promoter of Gsc, specifically recognizing methylated histone H3 lysine-9 and acetylated histone H3 lysine-18 and possibly opening chromatin at the promoter (Xi et al. 2011). |
| (summation) | [Reaction:9756964] p-2S-Smad2,3:Smad4 binds Foxh1:Smad3:Gsc gene [Mus musculus] |
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