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Details on Person UniProt:P07965 sta3
| Class:Id | ReferenceGeneProduct:9760332 |
|---|---|
| _chainChangeLog | signal peptide:1-19 for 9760332 added on Fri February 25 2022;propeptide:20-53 for 9760332 added on Fri February 25 2022;peptide:54-72 for 9760332 added on Fri February 25 2022 |
| _displayName | UniProt:P07965 sta3 |
| _timestamp | 2025-05-21 21:37:06 |
| chain | signal peptide:1-19 propeptide:20-53 peptide:54-72 |
| checksum | 1C5C9292BFCBA6BA |
| comment | FUNCTION Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.SUBCELLULAR LOCATION Linaclotide, sold as Linzess (Abbvie) in N. America and Constella (Astellas) elsewhere, is a derivative of this protein corresponding to residues 59 to 72 with Tyr-62. It is used to treat irritable bowel syndrome.SIMILARITY Belongs to the heat-stable enterotoxin family. |
| created | [InstanceEdit:9760325] Stephan, Ralf, 2021-12-16 |
| description | recommendedName: Heat-stable enterotoxin A3/A4 alternativeName: ST-H alternativeName: ST-IB alternativeName: STA3/STA4 innNameLinaclotide/innName |
| geneName | sta3 sta4 |
| identifier | P07965 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Enterotoxin Pharmaceutical Secreted Signal Toxin Virulence |
| modified | [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | sta3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | HST3_ECOLX P26588 |
| sequenceLength | 72 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9760327] pro-Sta3 [periplasmic space] [Escherichia coli] [EntityWithAccessionedSequence:9760334] prepro-Sta3 [cytosol] [Escherichia coli] [EntityWithAccessionedSequence:9760534] Sta3-SH [periplasmic space] [Escherichia coli] [EntityWithAccessionedSequence:9760547] Sta3 [periplasmic space] [Escherichia coli] [EntityWithAccessionedSequence:9760579] Sta3 [extracellular region] [Escherichia coli] [EntityWithAccessionedSequence:9911385] prepro-Sta3 [periplasmic space] [Escherichia coli] |
| (referenceSequence) | [IntraChainCrosslinkedResidue:9760550] Intra-chain Crosslink via L-cystine (cross-link) at 59 and 64 [IntraChainCrosslinkedResidue:9760553] Intra-chain Crosslink via L-cystine (cross-link) at 63 and 71 [IntraChainCrosslinkedResidue:9760560] Intra-chain Crosslink via L-cystine (cross-link) at 60 and 68 |
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No pathways have been reviewed or authored by UniProt:P07965 sta3 (9760332)
