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Details on Person AcK-NFE2L2 binds the GCLC gene

Class:Id	Reaction:9760099
_displayName	AcK-NFE2L2 binds the GCLC gene
_doRelease	TRUE
_timestamp	2022-02-28 16:31:50
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9760100] Rothfels, Karen, 2021-12-14
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[EntityWithAccessionedSequence:5662569] GCLC gene [nucleoplasm] [Homo sapiens] [Complex:9760062] p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9759999] Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase [LiteratureReference:9759995] Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray [LiteratureReference:9759034] The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes [LiteratureReference:9759989] Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response
modified	[InstanceEdit:9766998] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AcK-NFE2L2 binds the GCLC gene
output	[Complex:9760073] GCLC gene:p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9760081] CREBBP, EP300 acetylates NFE2L2 [Homo sapiens] [Reaction:9760082] NFE2L2 binds CREBBP,EP300 [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9760101] R-HSA-9760099.2
summation	[Summation:9760049] The GCLC gene encodes the catalytic heavy chain subunit of g...
(hasEvent)	[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9760122] AcK-NFE2L2-dependent GCLC gene expression [Homo sapiens]
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No pathways have been reviewed or authored by AcK-NFE2L2 binds the GCLC gene (9760099)