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Details on Person SRXN1 reduces hyperoxidized PRDX1 dimer

Class:Id	Reaction:9760094
_displayName	SRXN1 reduces hyperoxidized PRDX1 dimer
_doRelease	TRUE
_timestamp	2022-02-28 16:33:46
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:9760092] sulfiredoxin activity of SRXN1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9760093] Rothfels, Karen, 2021-12-14
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[Complex:5631882] HOOS-C52-PRDX1 dimer [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9759294] Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine [LiteratureReference:9759290] Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins
modified	[InstanceEdit:9767054] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767217] Rothfels, Karen, 2022-02-25 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRXN1 reduces hyperoxidized PRDX1 dimer
negativePrecedingEvent	[NegativePrecedingEvent:9767153] Futile Cycle: PRDX1 overoxidizes
output	[Complex:3341319] PRDX1 dimer [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[BlackBoxEvent:9759358] NFE2L2-dependent SRXN1 gene expression [Homo sapiens] [Reaction:9759334] NFE2L2 binds the SRXN1 gene [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9760095] R-HSA-9760094.2
summation	[Summation:9760055] SRXN1 is a sulfiredoxin protein that reduces hyperoxidized m...
(hasEvent)	[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9767156] Futile Cycle: SRXN1 reduces hyperoxidized PRDX1 dimer
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No pathways have been reviewed or authored by SRXN1 reduces hyperoxidized PRDX1 dimer (9760094)