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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person ITCH [cytosol]

Class:IdEntityWithAccessionedSequence:975995
_displayNameITCH [cytosol]
_timestamp2017-03-31 13:22:14
compartment[Compartment:70101] cytosol
created[InstanceEdit:976001] Garapati, P V, 2010-10-11
endCoordinate903
modified[InstanceEdit:1248665] Jupe, S, 2011-04-11
[InstanceEdit:3448660] Wu, G, 2013-05-16
[InstanceEdit:8983918] Jupe, Steve, 2017-03-31
nameITCH
E3 ubiquitin-protein ligase Itchy homolog
ITCH_HUMAN
AIP4
referenceEntity[ReferenceGeneProduct:93459] UniProt:Q96J02 ITCH [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1108208] R-HSA-975995.2
startCoordinate1
(activeUnit)[CatalystActivity:5621778] ubiquitin protein ligase activity of NUMB:ITCH [cytosol]
[CatalystActivity:5635830] ubiquitin protein ligase activity of GLI1:NUMB:ITCH [cytosol]
(hasCandidate)[CandidateSet:976075] E3 ligases in proteasomal degradation [cytosol] [Homo sapiens]
(hasComponent)[Complex:983459] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:PCBP2:ITCH [mitochondrial outer membrane] [Homo sapiens]
[Complex:1604453] DTX:ITCH [cytosol] [Homo sapiens]
[Complex:1604458] NOTCH1:NUMB:ITCH [plasma membrane] [Homo sapiens]
[Complex:1911536] Ub-DTX:ITCH [cytosol] [Homo sapiens]
[Complex:1911544] Ub-NOTCH1:NUMB:ITCH [plasma membrane] [Homo sapiens]
[Complex:5610562] NUMB:ITCH [cytosol] [Homo sapiens]
[Complex:9685173] 9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane] [Homo sapiens]
[Complex:9793452] p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] [Homo sapiens]
(hasMember)[CandidateSet:1248659] RIP2 ubiquitin ligases [cytosol] [Homo sapiens]
[DefinedSet:1253275] WWP1/ITCH [cytosol] [Homo sapiens]
[CandidateSet:8852047] HECT-type E3 ubiquitin ligase [cytosol] [Homo sapiens]
(input)[Reaction:990526] Recruitment of ITCH and K48 ubiquitination of MAVS [Homo sapiens]
[Reaction:1980125] ITCH binds DTX [Homo sapiens]
[Reaction:1980128] NOTCH1 associates with negative regulators NUMB and ITCH [Homo sapiens]
[Reaction:5610735] NUMB binds ITCH [Homo sapiens]
[BlackBoxEvent:9685195] SARS-CoV-1 9b recruits ITCH to MAVS [Homo sapiens]
[Reaction:9793451] MLKL binds ITCH [Homo sapiens]
(output)[BlackBoxEvent:8954554] Upregulated expression of ITCH [Homo sapiens]
[BlackBoxEvent:8956652] ITCH gene expression is stimulated by RUNX1 and YAP1 [Homo sapiens]
[BlackBoxEvent:9793444] ITCH polyubiquitinates MLKL at K50 [Homo sapiens]
(physicalEntity)[CatalystActivity:990525] ubiquitin protein ligase activity of ITCH [cytosol]
(updatedInstance)[_UpdateTracker:9897057] Update Tracker - [EntityWithAccessionedSequence:975995] ITCH [cytosol] - v61:[addName]
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No pathways have been reviewed or authored by ITCH [cytosol] (975995)
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