Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person In cancer cells it has been shown that Snail (SNAI1) protein...
| Class:Id | Summation:9759755 |
|---|---|
| _displayName | In cancer cells it has been shown that Snail (SNAI1) protein... |
| _timestamp | 2024-12-15 12:41:38 |
| created | [InstanceEdit:9759756] May, Bruce, 2021-12-11 |
| literatureReference | [LiteratureReference:9756406] The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition [LiteratureReference:9766453] Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition [LiteratureReference:9756426] A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition |
| modified | [InstanceEdit:9794590] May, Bruce, 2022-07-18 [InstanceEdit:9932012] Orlic-Milacic, Marija, 2024-12-15 [InstanceEdit:9932013] Orlic-Milacic, Marija, 2024-12-15 |
| text | In cancer cells it has been shown that Snail (SNAI1) protein binds the promoter of the E-Cadherin (CDH1) gene and represses expression of CDH1 (Batlle et al. 2000, Maturi et al. 2018, and inferred from mouse homologs). Repression of CDH1 by SNAI1 results in a reduction in CDH1 protein at the plasma membrane that causes loss of contact between epithelial cells during the epithelial to mesenchyme transition that is required for mesoderm formation (inferred from mouse embryos). SNAI1 efficient repression and binding to human and mouse CDH1 promoter require intact zinc finger motifs ZF1 and ZF2 (Villarejo et al. 2014). SMAD3:SMAD4 heterotrimer may be involved in the recruitment of SNAI1 to the CDH1 gene promoter (Vincent et al. 2009). |
| (summation) | [Reaction:9756414] SNAI1 binds the CDH1 gene [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by In cancer cells it has been shown that Snail (SNAI1) protein... (9759755)
