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Details on Person Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform

Class:Id	BlackBoxEvent:9759522
_displayName	Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform
_doRelease	TRUE
_timestamp	2023-04-19 10:04:56
authored	[InstanceEdit:9793111] Orlic-Milacic, Marija, 2022-06-02
catalystActivity	[CatalystActivity:9759527] metallopeptidase activity of (ADAM33,ADAM19)
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9759523] Orlic-Milacic, Marija, 2021-12-06
edited	[InstanceEdit:9833282] Orlic-Milacic, Marija, 2023-04-19
input	[EntityWithAccessionedSequence:418979] CDH11 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9759489] Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11
modified	[InstanceEdit:9759535] Orlic-Milacic, Marija, 2021-12-06 [InstanceEdit:9759545] Orlic-Milacic, Marija, 2021-12-06 [InstanceEdit:9793119] Orlic-Milacic, Marija, 2022-06-02 [InstanceEdit:9833282] Orlic-Milacic, Marija, 2023-04-19 [InstanceEdit:9833283] Orlic-Milacic, Marija, 2023-04-19 [InstanceEdit:9835794] Matthews, Lisa, 2023-05-17
name	Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform
output	[EntityWithAccessionedSequence:9759530] CDH11(54-?) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9759528] CDH11(?-796) [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9759513] CDH11 canonical mRNA is translated into CDH11 canonical protein isoform [Homo sapiens] [BlackBoxEvent:9759496] CDH11 nascent mRNA is spliced into the canonical splicing isoform [Homo sapiens]
releaseDate	2023-06-07
reviewed	[InstanceEdit:9833280] Brasch, Julia, 2023-04-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9759524] R-HSA-9759522.1
summation	[Summation:9759526] The canonical isoform of human CDH11, but not the variant is...
(hasEvent)	[Pathway:9762292] Regulation of CDH11 function [Homo sapiens]
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