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Details on Person LRP2 binds extracellular TCN2:RCbl

Class:IdReaction:9759209
_displayNameLRP2 binds extracellular TCN2:RCbl
_doReleaseTRUE
_timestamp2022-03-02 16:26:46
authored[InstanceEdit:9759205] D'Eustachio, Peter, 2021-11-29
catalystActivity[CatalystActivity:350169] cargo receptor activity of LRP2:LDLRAP1 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9759203] cargo receptor activity of LRP2:LDLRAP1 [plasma membrane] Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9759205] D'Eustachio, Peter, 2021-11-29
edited[InstanceEdit:9759205] D'Eustachio, Peter, 2021-11-29
input[Complex:9759429] TCN2:RCbl [extracellular region] [Homo sapiens]
[Complex:9759635] LRP2:LDLRAP1 [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:350114] Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties
[LiteratureReference:350124] Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin
[LiteratureReference:9758741] Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis
[LiteratureReference:9758734] The adaptor protein ARH escorts megalin to and through endosomes
[LiteratureReference:9758823] ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression
modified[InstanceEdit:9759214] D'Eustachio, Peter, 2021-11-29
[InstanceEdit:9759435] D'Eustachio, Peter, 2021-12-03
[InstanceEdit:9759636] D'Eustachio, Peter, 2021-12-09
[InstanceEdit:9764259] D'Eustachio, Peter, 2022-02-10
[InstanceEdit:9764574] D'Eustachio, Peter, 2022-02-11
[InstanceEdit:9764875] D'Eustachio, Peter, 2022-02-14
[InstanceEdit:9764894] D'Eustachio, Peter, 2022-02-14
[InstanceEdit:9767978] D'Eustachio, Peter, 2022-03-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLRP2 binds extracellular TCN2:RCbl
negativePrecedingEvent[NegativePrecedingEvent:9764880] Futile Cycle: LRP2-mediated TCN2:RCbl uptake and delivery to lysosome
[NegativePrecedingEvent:9764881] Different Cell Type: TCN2 binds RCbl in the circulation
output[Complex:9759208] LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] [Homo sapiens]
releaseDate2022-03-23
reviewed[InstanceEdit:9764895] Hill, David P, 2022-02-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9759213] R-HSA-9759209.2
summation[Summation:9759204] Plasma membrane-associated LRP2 (megalin, glycoprotein 330) ...
(hasEvent)[Pathway:9758890] Transport of RCbl within the body [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9759202] LRP2-mediated TCN2:RCbl uptake and delivery to lysosome [Homo sapiens]
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