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Details on Person KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer

Class:Id	Reaction:9759172
_displayName	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
_doRelease	TRUE
_timestamp	2022-02-28 16:32:29
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:9759171] ubiquitin protein ligase activity of p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9759173] Rothfels, Karen, 2021-11-29
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[Complex:9759099] p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9759008] Regulation of selective autophagy: the p62/SQSTM1 paradigm [LiteratureReference:9758982] Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9759000] Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway [LiteratureReference:9759058] p62 links autophagy and Nrf2 signaling
modified	[InstanceEdit:9762212] Rothfels, Karen, 2022-01-18 [InstanceEdit:9766548] Rothfels, Karen, 2022-02-22 [InstanceEdit:9766667] Rothfels, Karen, 2022-02-23 [InstanceEdit:9766707] Rothfels, Karen, 2022-02-23 [InstanceEdit:9767016] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
output	[Complex:9766542] ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9759169] p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 [Homo sapiens] [Reaction:9766532] SQSTM1 oligomer is phosphorylated [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9759174] R-HSA-9759172.2
summation	[Summation:9762198] SQSTM1 is an adaptor protein that mediates aggregation of ta...
(hasEvent)	[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
(precedingEvent)	[Reaction:9766687] SESN1,SESN1 bind SQSTM1 and KEAP1 [Homo sapiens]
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No pathways have been reviewed or authored by KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (9759172)