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Details on Person p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1

Class:Id	Reaction:9759169
_displayName	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
_doRelease	TRUE
_timestamp	2022-02-28 16:34:00
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9759167] Rothfels, Karen, 2021-11-29
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input	[Complex:8932333] KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Homo sapiens] [Complex:9766527] p-S349 SQSTM1 oligomer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9759063] p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription [LiteratureReference:9766496] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway [LiteratureReference:9758982] Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination [LiteratureReference:9759000] Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway [LiteratureReference:9759058] p62 links autophagy and Nrf2 signaling [LiteratureReference:9766515] Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage [LiteratureReference:9766507] Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1
modified	[InstanceEdit:9766548] Rothfels, Karen, 2022-02-22 [InstanceEdit:9767060] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767218] Rothfels, Karen, 2022-02-25 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
negativePrecedingEvent	[NegativePrecedingEvent:9767158] Futile Cycle: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
output	[Complex:9759099] p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9766532] SQSTM1 oligomer is phosphorylated [Homo sapiens] [Reaction:9759158] SQSTM1 oligomerizes [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9759170] R-HSA-9759169.2
summation	[Summation:9759168] SQSTM1 binds to the KEAP1 subunit of the CRL3 ubiquitin liga...
(hasEvent)	[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
(precedingEvent)	[Reaction:9759172] KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer [Homo sapiens]
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No pathways have been reviewed or authored by p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (9759169)