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Details on Person TRIM21 ubiquitinates SQSTM1

Class:IdReaction:9759154
_displayNameTRIM21 ubiquitinates SQSTM1
_doReleaseTRUE
_timestamp2022-02-28 16:33:48
authored[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity[CatalystActivity:9759151] ubiquitin protein ligase activity of TRIM21 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9759153] Rothfels, Karen, 2021-11-29
edited[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
input[EntityWithAccessionedSequence:193937] SQSTM1 [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9759025] TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis
[LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
modified[InstanceEdit:9766705] Rothfels, Karen, 2022-02-23
[InstanceEdit:9767055] Rothfels, Karen, 2022-02-24
[InstanceEdit:9767541] Rothfels, Karen, 2022-02-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTRIM21 ubiquitinates SQSTM1
output[EntityWithAccessionedSequence:9759088] K7 ub-SQSTM1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2022-03-23
reviewed[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9759155] R-HSA-9759154.2
summation[Summation:9759152] E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7,...
(hasEvent)[Pathway:9755511] KEAP1-NFE2L2 pathway [Homo sapiens]
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