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Details on Person E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7,...
| Class:Id | Summation:9759152 |
|---|---|
| _displayName | E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7,... |
| _timestamp | 2021-11-29 20:41:14 |
| created | [InstanceEdit:9759153] Rothfels, Karen, 2021-11-29 |
| text | E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7, inhibiting SQSTM1 oligomerization and therefore its ability to sequester and degrade ubiquitinated proteins (Pan et al, 2016). Among the proteins targeted by SQSTM1 is KEAP1, a negative regulator of redox response through KEAP1-mediated degradation of NFE2L2 (reviewed in Baird and Yamamoto, 2020). |
| (summation) | [Reaction:9759154] TRIM21 ubiquitinates SQSTM1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by E3 ubiquitin ligase TRIM21 ubiquitinates SQSTM1 at lysine 7,... (9759152)
