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Details on Person NFE2L2 and MAFK bind the HMOX1 gene

Class:Id	Reaction:9759137
_displayName	NFE2L2 and MAFK bind the HMOX1 gene
_doRelease	TRUE
_timestamp	2022-02-28 16:32:47
authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9759133] Rothfels, Karen, 2021-11-29
edited	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
inferredFrom	[Reaction:9759134] Nfe2l2 and MafK bind Hmox1 gene [Gallus gallus]
input	[EntityWithAccessionedSequence:6789487] HMOX1 gene [nucleoplasm] [Homo sapiens] [CandidateSet:9708562] p-NFE2L2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1008242] MAFK [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9759015] Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism [LiteratureReference:9758967] A review on heme oxygenase-1 induction: is it a necessary evil [LiteratureReference:9708514] Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
modified	[InstanceEdit:9767024] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767159] Rothfels, Karen, 2022-02-24 [InstanceEdit:9767209] Rothfels, Karen, 2022-02-25 [InstanceEdit:9767541] Rothfels, Karen, 2022-02-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFE2L2 and MAFK bind the HMOX1 gene
output	[Complex:9759123] HMOX1 gene:p-NFE2L2:MAFK [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:8932309] NFE2L2 translocates from cytosol to nucleoplasm [Homo sapiens] [BlackBoxEvent:8932322] CK2 phosphorylates NFE2L2 [Homo sapiens] [Reaction:8932284] PKC phosphorylates NFE2L2 [Homo sapiens] [Reaction:9708557] FBXL17 binds BACH1:MAFK [Homo sapiens] [Reaction:9707690] BACH1 binds MAFK [Homo sapiens]
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9759139] R-HSA-9759137.2
summation	[Summation:9759136] The HMOX1 gene encodes heme oxygenase, which converts free h...
(hasEvent)	[Pathway:9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9759176] NFE2L2-dependent HMOX1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by NFE2L2 and MAFK bind the HMOX1 gene (9759137)